Ajay Arya

(Doctoral candidate; June 25, 2016 onwards)

Primary affiliation: Completed M. Tech. in Bioinformatics from University of Hyderabad

Research Interests: I am interested in machine learning (classical and deep learning) techniques to predict DNA-protein interactions, drug resistance prevalence/pattern and binding/active sites of DNA or proteins. I am interested in applications of these methods to the development of new drugs/vaccines and disease diagnosis.

Current ProjectIn my M.Tech. research project I worked on “Prevalence of HIV-1 Reverse Transcriptase Drug Resistance in India.” In this we investigated the patterns of prevalent drug resistance mutations in HIV patients in India. As an extension of that work, I am currently interested in developing a tool to predict the prevalence and pattern of drug resistance from reverse transcriptase sequence and mutant information extracted from clinical data.

Aditya Bajaj

(Research Intern (Completed); June 25-October 30, 2016)

Primary affiliation: Integrated M.Sc. – Ph.D. in Molecular Medicine at the Special Centre for Molecular Medicine, Jawaharlal Nehru University

Research Interests: Broadly include Medical Microbiology- molecular basis of infectious diseases, host microbe relationships and human gut microbiome and its roles to modulate human physiological processes. In future I would like to emphasise on bacterial biofilms and quorum sensing in health and diseases and to study aspects of microbial antibiotic resistance and nosocomial infections.

Project completed To utilise Computational biology tools to study the Spoligotyping patterns in different members of Mycobacterium tuberculosis complex (MTBC). Spacer oligonucleotide typing, or spoligotyping, is a rapid, polymerase chain reaction (PCR)-based method for genotyping strains of the Mycobacterium tuberculosis complex. The project aims to decipher links between these spoligotyping patterns and the clinical and epidemiological characteristics of various Mycobacterial strains.

News about members

October 30, 2016: Manasvani completed her project.

October 30, 2016:Aditya completed his project.

June 25, 2016:Ajay started his project.

Manasvini Markandey

(Research Intern (Completed); June 25-October 30, 2016)

Primary affiliation: Currently pursuing MSc Biotechnology at Faculty of Life Sciences & Biotechnology, South Asian University, New Delhi Previous Qualification: BSc (H) Microbiology, Ram Lal Anand College, University of Delhi

Research Interests: My interest lies in the field of medical microbiology. Particularly I wish to study the molecular basis of host-pathogen interactions and unravelling how the host physiology is altered as an infection ensues. Furthermore, I wish to develop on these mechanisms to design drugs that can possibly be used to cure the common, yet severe diseases. Another field of interest to me is the resident micro-flora of the human body and its effects on the host physiology. These microbes aren’t pathogenic, but can turn from friends to foes under certain circumstances. Studying the mechanisms by which this symbiotic relationship operates in its bidirectional fashion is a key area of research these days, since it’s now known that these micro-organisms may play substantial roles in altering the vulnerability of the human system towards various pathogenic infections.

Project completed: To use bioinformatic tools to identify the genes and proteins in host system and the respective pathogenic molecules of Zika Virus interacting with these host molecules, so as to be able to define an outlining network of host-pathogen interactions underlying ZIKV infection in humans. We’d also like to extend it by carrying out co-infection analysis and identifying other pathogens that share similar molecular pathways during infection.